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KMID : 0605720010070010012
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Journal of the Korean Society of Biological Therapies in Psychiatry
2001 Volume.7 No. 1 p.12 ~ p.21
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Pharmacotherapy for Obsessive Compulsive Disorder
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Ki Sun-Wan
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Abstract
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The author reviewed pharmacotherapy for ovsessive compulsive disorder. Serotonin reuptake inhibitors(SRIs) and the tricyclic antidepressant clomipramine are the first line therapies for patients with obsessive compulsive disorder(OCD), with the side-effect profile of selective SRIs(SSRIs) being more favorable than clomipramine. As many as 40% to 60% of patients with OCD may not response to adequate trials of SRIs. Not all patients tolerate SSRIs, and delay in full therapeutic responses often occur. Thus, other pharmacological approaches to treating patients with OCD have been investigated. Augmentation and monotherapy have been explored with serotonergic enhancers, dopamine and 5-HT antagonists, enhancers of second-messenger systems, and GABAergic agents with varying efficacy.
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KEYWORD
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Obsessive compulsive disorder, Pharmacotherapy, SSRIs
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